Figure 7.

Effect of IRAK-M deficiency on the differentiation of naive CD4⁺ T cells. (A) Baseline mRNA expression of IRAK-M by splenocytes, Th cells, and naive CD4⁺ T cells isolated from WT mice. (B) Flow cytometry analysis of in vitro differentiation of WT or IRAK-M KO naive CD4⁺ T cells to specific T cell subsets after a 5-day incubation with various colony-stimulating factors. (C) Representative flow cytometric images and summary plot of IκBζ expression in Th17 cells from WT or IRAK-M KO mice after activation. n = 10 mice in each group; *P < 0.05.