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. 2020 Jan 6;27:19. doi: 10.1186/s12929-019-0597-7

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of G-CSF on expression of GRP78, CHOP and ER stress proteins. a GRP78 levels in the frontal (F _{(2, 18)} = 9.549, p = 0.0015) and middle F _{(2, 12)} = 283.3, p < 0.0001) region of brain on day 4. b GRP78 levels in the frontal (F _{(2, 15)} = 4.378, p = 0.0318) and middle (F _{(2, 14)} = 4.787, p = 0.0261) region of brain on day 7. c CHOP levels in the ischemic frontal (F _{(2, 21)} = 10.77, p = 0.0006) and middle (F _{(2, 11)} = 74.31, p < 0.0001) region of brain on day 4. d Levels of CHOP in the ischemic frontal (F _{(2, 14)} = 6.101, p = 0.0473) and middle (F _{(2, 20)} = 26.63, p < 0.0001) region of brain on day 7. e Cleaved ATF6 levels in the frontal (F _{(2, 27)} = 5.464, p = 0.0102) and middle (F _{(2, 26)} = 6.514, p = 0.0051) region of brain. f ATF4 levels in the frontal (F _{(2, 15)} = 4.084, p = 0.0384) and middle (F _{(2, 13)} = 3.965, p = 0.0452) region of brain. g eIF2α levels in the ischemic frontal (F _{(2, 8)} = 5.671, p = 0.0293) and middle (F _{(2, 11)} = 21.24, p = 0.0002) regions of brain. h XBP1 levels in the frontal (F _{(2, 12)} = 10.29, p = 0.0025) and middle (F _{(2, 7)} = 19.53, p = 0.0014) region of brain. i Cleaved caspase-12 levels in the ischemic frontal (F _{(2, 9)} = 8.165, p = 0.0095) and middle (F _{(2, 11)} = 5.357, p = 0.0238) regions of brain. Representative western blots are presented with cropped blot panels showing target protein signals and control (GAPDH) protein signals in separate panels derived from the same gel. Graphs shows mean ± SEM. * and # significant compared to sham & vehicle treated groups, respectively by ANOVA and Tukey post hoc tests (n = 5, p < 0.05)