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. 2020 Jan 6;18:2. doi: 10.1186/s12916-019-1469-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Differential gene expression analysis. a–c Principal component analysis (PCA) of mRNAs (a), lncRNAs (b), and microRNAs (miRNAs) (c), respectively. Each dot represents one sample. Blue: heart failure (HF) samples. Red: control samples. d–f Volcano plots showing mRNA (d), lncRNA (e), and miRNA (f) differential expression. Red and blue dots denote significantly upregulated and downregulated genes, respectively. g–i Heatmap plots showing differentially expressed mRNAs, lncRNAs, and miRNAs among the samples. X-axis: sample IDs starting with a D denote HF samples and samples with a C for control samples