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. 2020 Jan 6;18:2. doi: 10.1186/s12916-019-1469-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Gene expression regulatory networks in heart failure. a microRNA-mRNA regulatory network. b lncRNA-mRNA regulatory network. c microRNA-lncRNA-mRNA co-regulatory network. mRNAs, microRNAs, and lncRNAs are denoted by circle, triangle, and pentagon nodes, respectively. Red, orange, and purple nodes are upregulated expression and other color for downregulated expression. The edges represent differently weighted regulation. Edge width is proportional to the Spearman correlation coefficient between the linking nodes. Here, an arrow indicates activation relation while an edge ending with -| indicates repression