Table 2.
Hazard ratios (HR) and 95% confidence intervals (CIs) for the association between endometrial cancer status and CVD mortality in the Iowa Women’s Health Study
| Characteristic | CVD Mortality | |
|---|---|---|
| Overall model | Deaths, n (%) a | HR (95% CI) b |
| Endometrial cancer status | ||
| No (n=2,352) | 413 (17.6) | 1.0 |
| Yes (n=552) | 71 (12.9) | 0.75 (0.56, 0.99) |
| Sensitivity analyses | ||
| Cases restricted to low-grade endometrioid endometrial cancer | ||
| Endometrial cancer status | ||
| No (n=2,352) | 413 (17.6) | 1.0 |
| Yes (n=389) | 56 (14.4) | 0.76 (0.55, 1.05) |
| Cases restricted to localized stage cancer | ||
| Endometrial cancer status | ||
| No (n=2,352) | 413 (17.6) | 1.0 |
| Yes (n=420) | 59 (14.0) | 0.75 (0.54, 1.02) |
| Restricted to women without prevalent CVD | ||
| Endometrial cancer status | ||
| No (n=2,021) | 317 (15.7) | 1.0 |
| Yes (n=464) | 56 (12.1) | 0.78 (0.56, 1.09) |
| Restricted to never smokers | ||
| Endometrial cancer status | ||
| No (n=1,584) | 266 (16.8) | 1.0 |
| Yes (n=403) | 52 (12.9) | 0.79 (0.55, 1.13) |
| Restricted to women with questionnaire data ≤5 years before the reference/diagnosis date | ||
| Endometrial cancer status | ||
| No (n=1,865) | 342 (18.3) | 1.0 |
| Yes (n=447) | 62 (13.9) | 0.88 (0.59, 1.34) |
a
row percentage
b
Adjusted for time between questionnaire completion and reference/diagnosis date, history of oral contraceptive use (never, ever), alcohol use (no, yes), diabetes (no, yes), hypertension (no, yes), prevalent CVD (no, yes), education (< high school, high school graduate, > high school), smoking status (never, former, current), and stratified by match set ID