Table 3.
Hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between patient characteristics and CVD mortality stratified by case status in the Iowa Women’s Health Study (1986–2011)
| Characteristic | CVD Mortality | |||||
|---|---|---|---|---|---|---|
| Women with endometrial cancer (deaths=71, N=552) |
Controls (deaths=413, N=2,352) |
|||||
| deaths, n (%) a | HR (95% CI) b | p | deaths, n (%) a | HR (95% CI) b | p | |
| Age at diagnosis | <0.001 | <0.001 | ||||
| <70 | 25 (11.6) | 1.00 | 157 (16.6) | 1.00 | ||
| 70–74 | 26 (18.6) | 3.24 (1.73, 6.09) | 107 (19.4) | 2.31 (1.77, 3.01) | ||
| ≥75 | 20 (10.2) | 3.93 (1.85, 8.36) | 149 (17.4) | 5.27 (3.92, 7.09) | ||
| Body mass index (BMI) | 0.09 | 0.31 | ||||
| <25 kg/m2 | 21 (14.1) | 1.00 | 118 (16.5) | 1.00 | ||
| 25–30 kg/m2 | 27 (15.3) | 1.21 (0.68, 2.18) | 171 (16.9) | 1.06 (0.84, 1.35) | ||
| 30–35 kg/m2 | 17 (11.0) | 0.68 (0.35, 1.33) | 93 (18.2) | 0.90 (0.68, 1.19) | ||
| ≥35 kg/m2 | 6 (8.3) | 0.42 (0.16, 1.11) | 31 (27.0) | 1.31 (0.87, 1.98) | ||
| Education | 0.35 | <0.001 | ||||
| Less than high school | 15 (16.7) | 1.00 | 116 (26.9) | 1.00 | ||
| High school graduate | 36 (12.4) | 0.69 (0.37, 1.27) | 191 (15.7) | 0.65 (0.52, 0.83) | ||
| Some college | 20 (11.7) | 0.61 (0.31, 1.21) | 105 (15.0) | 0.59 (0.45, 0.78) | ||
| Smoking status | 0.66 | <0.001 | ||||
| Never | 52 (12.9) | 1.00 | 266 (16.8) | 1.00 | ||
| Ever | 18 (13.0) | 0.77 (0.44, 1.36) | 139 (19.0) | 1.53 (1.24, 1.90) | ||
| Alcohol intake | 0.98 | 0.06 | ||||
| No | 45 (13.6) | 1.00 | 263 (20.0) | 1.00 | ||
| Yes | 26 (11.8) | 0.99 (0.60, 1.65) | 150 (14.4) | 0.82 (0.66, 1.01) | ||
| History of oral contraceptive use | 0.02 | 0.56 | ||||
| No | 57 (11.9) | 1.00 | 359 (18.7) | 1.00 | ||
| Yes | 14 (19.4) | 2.00 (1.09, 3.65) | 53 (12.3) | 1.01 (0.98, 1.03) | ||
| Diabetes | <0.001 | <0.001 | ||||
| No | 53 (11.1) | 1.00 | 359 (16.7) | 1.00 | ||
| Yes | 18 (23.7) | 4.31 (2.21, 8.06) | 54 (27.3) | 1.82 (1.35, 2.46) | ||
| Hypertension | 0.06 | <0.001 | ||||
| No | 30 (11.1) | 1.00 | 173 (13.3) | 1.00 | ||
| Yes | 41 (14.5) | 1.64 (0.99, 2.71) | 240 (22.8) | 1.82 (1.47, 2.24) | ||
| CVD | 0.99 | <0.001 | ||||
| No | 56 (12.1) | 1.00 | 317 (15.7) | 1.00 | ||
| Yes | 15 (17.0) | 1.00 (0.53, 1.89) | 96 (29.0) | 1.68 (1.32, 2.15) | ||
a
row percentage
b
HRs and 95% CIs adjusted for time between questionnaire completion and diagnosis), age at diagnosis, history of oral contraceptive use, prevalent diabetes, prevalent hypertension, prevalent cardiovascular disease, and surgery. All variables categorized as shown in table.
c
Twenty-one endometrioid cases with missing grade could not be further classified