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. Author manuscript; available in PMC: 2020 Jan 6.

Published in final edited form as: Int J Hyperthermia. 2019 Nov;36(SUP1):37–46. doi: 10.1080/02656736.2019.1627433

Figure 1. — The pathways highlighted (red and green) in the Kegg diagrams demonstrate significant differential expression, compared to control, for a variety of relevant genes following mNPH, radiation or both. The red boxes highlight the genes discussed within the paper, while the green boxes highlight the positive (immune stimulatory, anti-tumor) outcomes of these genetic changes. The diagrams illustrate how mNPH and mNPH + 8 Gy affect each pathway and the possible outcomes or effects of these changes with respect to apoptosis and immune response. The pathways illustrated are (a) the cytokine–cytokine receptor pathway and (b) the toll-like receptor signaling pathway. The comparison also visually demonstrates how the addition of radiation enhances or alters gene expression, compared to low dose hyperthermia alone.

Figure 1. — The pathways highlighted (red and green) in the Kegg diagrams demonstrate significant differential expression, compared to control, for a variety of relevant genes following mNPH, radiation or both. The red boxes highlight the genes discussed within the paper, while the green boxes highlight the positive (immune stimulatory, anti-tumor) outcomes of these genetic changes. The diagrams illustrate how mNPH and mNPH + 8 Gy affect each pathway and the possible outcomes or effects of these changes with respect to apoptosis and immune response. The pathways illustrated are (a) the cytokine–cytokine receptor pathway and (b) the toll-like receptor signaling pathway. The comparison also visually demonstrates how the addition of radiation enhances or alters gene expression, compared to low dose hyperthermia alone.