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. Author manuscript; available in PMC: 2020 Sep 26.
Published in final edited form as: J Phys Chem B. 2019 Sep 18;123(38):8065–8073. doi: 10.1021/acs.jpcb.9b08178

Figure 1.

Figure 1.

(Upper) Catalytic cycle of class A Flavin-dependent Monooxygenases (lower) Previously proposed mechanisms for hydroxylation of aromatic substrates using 3-methyl-orcinaldehyde as the example with selected labels for the atoms in the isoalloxazine ring of the FAD cofactor and the 3-methyl-orcinaladehyde (3MO) substrate