Table 3.

Association of venous non-compressibility at 1 month with late clinical, anatomical, and physiological outcomes

Clinical Outcome		Status of CFV at 1 Month			Status of FV and PV at 1 Month
		Non-compressible	Compressible	p-value	Either non-compressible	Both compressible	p-value
Overall Trial	Any PTS, n (%)	104/170 (61%)	205/447 (46%)	<0.001	241/464 (52%)	70/160 (44%)	0.07
	Moderate-or-Severe PTS, n (%)	51/170 (30%)	85/447 (19%)	0.003	108/464 (23%)	30/160 (19%)	0.23
	Villalta score at 24 montds, mean (SD)	5.2 (5.8)	4.0 (4.6)	0.10	4.4 (5.1)	3.9 (4.4)	0.24
	VCSS score at 24 montds, mean (SD)	2.7 (3.3)	2.1 (2.7)	0.21	2.5 (3.1)	1.7 (2.4)	0.02
	VEINES-QOL score at 24 montds, mean (SD)	73.2 (24)	81.4 (20)	0.004	79.2 (21)	79.3 (24)	0.26
Anatomical/Physiological Outcome		Status of CFV at 1 Month			Status of FV and PV at 1 Month
		Non-compressible	Compressible	p-value	Either non-compressible	Both compressible	p-value
Ultrasound Substudy	Non-compressible CFV at 12 months, n (%)	22/36 (61%)	1/83 (1%)	<0.001	18/93 (19%)	5/28 (18%)	0.86
	Non-compressible FV at 12 months, n (%)	23/36 (64%)	46/84 (55%)	0.35	67/94 (71%)	2/28 (7%)	<0.001
	Non-compressible PV at 12 months, n (%)	18/36 (50%)	53/84 (63%)	0.18	72/94 (77%)	0/28 (0%)	<0.001
	Obstruction score at 12 months, mean (SD)	0.2 (0.6)	0.1 (0.4)	0.15	0.1 (0.5)	0.04 (0.2)	0.33
	CFV diameter (mm), mean (SD)	2.8 (2.8)	0.05 (0.4)	<0.001	0.9 (2.1)	0.6 (1.5)	0.57
	PV diameter (mm), mean (SD)	2.0 (2.5)	2.8 (2.4)	0.07	3.3 (2.3)	0 (0.0)	<0.001
	Reflux score at 12 months, mean (SD)	3.0 (1.8)	2.8 (1.7)	0.57	3.2 (1.6)	1.9 (1.7)	0.002
	Any reflux present at 12 months, n (%)	31/36 (86%)	74/84 (88%)	0.76	88/95 (93%)	19/27 (70%)	0.002
	Deep reflux present at 12 months, n (%)	30/36 (83%)	71/84 (85%)	0.87	84/95 (88%)	19/27 (70%)	0.02

CFV=Common Femoral Vein, FV=Femoral Vein, PTS=Post-thrombotic syndrome, PV=Popliteal Vein, SD=Standard Deviation, VCSS=Venous Clinical Severity Score, VEINES-QOL=Venous Insufficiency Epidemiological and Economic Study Quality of Life