Table 4.

Association of 12-month venous sonographic outcomes with 24-month clinical outcomes in Ultrasound Sub-study

Clinical Outcome	Status of CFV at 12 Months			Status of FV and PV at 12 Months
	Non-compressible	Compressible	p-value	Either non-compressible	Both compressible	p-value
Any PTS, n (%)	19/23 (83%)	56/99 (57%)	0.02	54/84 (64%)	22/39 (56%)	0.40
Moderate-or-Severe PTS, n (%)	9/23 (39%)	22/99 (22%)	0.09	23/84 (27%)	8/39 (21%)	0.41
Villalta score at 24 montds, mean (SD)	6.4 (5.5)	4.2 (4.3)	0.06	4.8 (4.8)	4.1 (4.3)	0.45
VCSS score at 24 montds, mean (SD)	2.8 (2.7)	1.9 (2.5)	0.11	2.4 (2.7)	1.5 (2.2)	0.05
VEINES-QOL score at 24 montds, mean (SD)	72.2 (19)	79.7 (22)	0.08	77.9 (21)	78.8 (24)	0.37
Clinical Outcome	Any Reflux at 12 Months			Deep Reflux at 12 Months
	Yes	No	p-value	Yes	No	p-value
Any PTS, n (%)	68/108 (63%)	8/15 (53%)	0.47	65/104 (63%)	11/19 (58%)	0.70
Moderate-or-Severe PTS, n (%)	32/108 (30%)	0/15 (0%)	0.01	31/104 (30%)	1/19 (5%)	0.02
Villalta score at 24 months, mean (SD)	4.9 (4.8)	2.7 (2.7)	0.10	4.9 (4.8)	3.2 (3.1)	0.23
VCSS score at 24 months, mean (SD)	2.3 (2.6)	1.3 (1.9)	0.12	2.3 (2.7)	1.4 (1.8)	0.24
VEINES-QOL score at 24 months, mean (SD)	77.3 (22)	82.0 (20)	0.39	77.5 (22)	79.9 (22)	0.53

CFV=Common Femoral Vein, FV=Femoral Vein, PTS=Post-thrombotic syndrome, PV=Popliteal Vein, SD=Standard Deviation, VCSS=Venous Clinical Severity score, VEINES-QOL=Venous Insufficiency Epidemiological and Economic Study Quality of Life