Table 2.

Correlation analysis between the transcriptional profile of Mtb-Specific CD4 + T cells and clinical data from HIV-TB patients. Table shows the results of CD4 + T cells expressing (A) CD25, FoxP3, ROR-γt or T-bet and the co-expression of FoxP3, ROR-γt and T-bet. Additionally, (B) Tregs (CD25 + FoxP3+) and uTregs (CD25-FoxP3+) subsets and the co-expression of the transcription factors ROR-γt or T-bet within each subpopulation were analyzed. A comparison of the percentage of different CD4+ Th cells was performed with total and nadir CD4 + T cell counts, CD4/CD8 ratio and viral load. Number of values (n), Spearman’s rank correlation coefficient (r), and p value are indicated

Clinical parameter	FoxP3+	ROR-γt+	T-bet+	CD25+	FoxP3+ ROR-γt+	ROR-γt + T-bet+	FoxP3+ T-bet+
A
CD4 + T cell count (cell/ml)	n = 14	n = 14	n = 15	n = 15	n = 14	n = 14	n = 15
	r = −0.66	r = 0.14	r = 0.48	r = − 0.45	r = 0.29	r = 0.37	r = − 0.49
	p = 0.0035	p = 0.31	p = 0.041	p = 0.045	p = 0.16	p = 0.19	p = 0.029
Nadir CD4 T cell count (cell/ml)	n = 15	n = 14	n = 14	n = 15	n = 14	n = 14	n = 15
	r = −0.65	r = 0.55	r = 0.65	r = − 0.41	r = 0.091	r = 0.61	r = − 0.29
	p = 0.021	p = 0.45	p = 0.014	p = 0.22	p = 0.40	p = 0.033	p = 0.28
CD4/CD8 T cell ratio	n = 15	n = 14	n = 15	n = 15	n = 14	n = 14	n = 15
	r = −0.55	r = − 0.12	r = 0.23	r = − 0.27	r = − 0.034	r = 0.13	r = − 0.17
	p = 0.018	p = 0.35	p = 0.21	p = 0.16	p = 0.49	p = 0.63	p = 0.27
Viral load (copies/ml)	n = 15	n = 14	n = 15	n = 15	n = 14	n = 14	n = 15
	r = 0.56	r = 0.25	r = − 0.14	r = 0.41	r = 0.15	r = 0.013	r = 0.071
	p = 0.015	p = 0.19	p = 0.32	p = 0.13	p = 0.30	p = 0.97	p = 0.80
B
Clinical parameter	Tregs	Tregs ROR-γt+	Tregs T-bet+	uTregs	uTregs ROR-γt+	uTregs T-bet+
CD4 + T cell count (cell/ml)	n = 15	n = 14	n = 15	n = 15	n = 14	n = 15
	r = −0.71	r = 0.33	r = − 0.17	r = − 0.48	r = 0.059	r = − 0.22
	p = 0.015	p = 0.25	p = 0.54	p = 0.036	p = 0.84	p = 0.42
Nadir CD4 T cell count (cell/ml)	n = 15	n = 15	n = 14	n = 14	n = 14	n = 14
	r = − 0.43	r = 0.16	r = − 0.19	r = − 0.29	r = − 0.27	r = − 0.22
	p = 0.090	p = 0.66	p = 0.58	p = 0.19	p = 0.44	p = 0.49
CD4/CD8 T cell ratio	n = 15	n = 14	n = 15	n = 15	n = 14	n = 15
	r = − 0.53	r = 0	r = − 0.17	r = − 0.27	r = − 0.059	r = − 0.16
	p = 0.022	p = 0.50	p = 0.55	p = 0.15	p = 0.84	p = 0.55
Viral Load (copies/ml)	n = 14	n = 14	n = 14	n = 14	n = 14	n = 14
	r = 0.42	r = 0.0083	r = − 0.23	r = 0.17	r = − 0.033	r = − 0.14
	p = 0.14	r = 0.98	p = 0.43	p = 0.27	p = 0.92	p = 0.63