Figure 10.

Tumor targeting of renal clearable NIR-emitting GS-AuNPs and gluathione-coated sub-nanometer gold clusters through the enhanced permeability and retention (EPR) effect. A) Representative in vivo NIR fluorescence images of mice bearing MCF-7 breast cancer xenografts at 0.5, 3, and 12 h after intravenous injection of GS-AuNPs (Ex/Em filters: 470/830 nm). Reproduced with permission from Ref. [35]. Copyright 2013, American Chemical Society. B) Bright-field and fluorescence images of glioma-bearing brain slices with (“AuNPs 24 h p.i.”) or without (“Control”) intravenous injection of GS-AuNPs. C) Tumor/cortex fluorescence ratios showed a 4.6-fold increase from “Control” to “AuNPs 24 h p.i.”. Reproduced with permission from Ref. [73]. Copyright 2017, Tsinghua University Press and Springer-Verlag Berlin Heidelberg. D) The linear relationship between tumor-targeting efficiencies of gold clusters in xenograft model of MCF-7 at 24 h p.i. and area under the pharmacokinetics curve (AUC) (n = 3). Reproduced with permission from Ref. [47]. Copyright 2017, Nature Publishing Group.