Figure 12.
Evaluation of renal function and structure of kidney filtration barrier of CD-1 mice after intravenous injection of renal clearable NIR-emitting GS-AuNPs with core size of 2.5 nm at doses from 15 to 183, 365, 693, and 1059 mgkg−1. A) Levels of serum creatinine (sCr) and B) blood urea nitrogen (BUN) were monitored within 14 days after NP injection. Mice receiving PBS served as control (n =4 for each group, *P< 0.05). Representative transmission electron microscopy (TEM) images of C) glomeruli and D) glomerular filtration membranes were taken from mice injected with 1059 mgkg−1 GS-AuNPs at Day 1 and Day 14. V= vascular lumen, B= Bowman’s space, arrows point the direction of filtration. Reproduced with permission from Ref. [58]. Copyright 2017, John Wiley and Sons.