Table 3–

Final Multivariate Linear Regression Models for each Neuroperformance Test (Imputed sample, n = 976)

	PSTa (n = 840)	CSTb (n = 476)	MDT (dominant hand)c (n = 880)	MDT (nondominant hand)c(n = 880)
Sex (female)	0.04 (−0.01, 0.10)	--	0.05 (−0.01, 0.11)	--
Age	-0.26 (−0.32, −0.20)*	-0.34 (−0.43, −0.26)*	--	--
Disease duration	-0.06 (−0.12, −0.01)*	--	--	--
PDDS	--	0.12 (−0.001, 0.25)	-0.14 (−0.23, −0.05)*	-0.10 (−0.19, −0.02)*
PROMIS-10 physical	0.08 (0.02, 0.13)*	--	0.06 (0.002, 0.12)*	--
Neuro-QoL Upper Extremity	0.15 (0.08, 0.23)*	0.09 (−0.03, 0.20)	0.25 (0.16, 0.33)*	0.23 (0.15, 0.32)*
Neuro-QoL Lower Extremity	0.13 (0.05, 0.22)*	0.23 (0.08, 0.39)*	0.11 (0.001, 0.23)*	0.23 (0.12, 0.34)*
T2 Lesion Volume	−0.02 (−0.29, −0.16)*	−0.08 (−0.18, 0.02)	−0.12 (−0.20, −0.05)*	−0.11 (−0.18, −0.05)*
Whole Brain Fraction	0.15 (0.07, 0.22)*	--	0.09 (0.01, 0.17)*	0.13 (0.07, 0.19)*
Thalamic Volume	--	0.10 (−0.02, 0.20)	0.07 (−0.01, 0.16)	--
Cord Area	--	0.06 (−0.02, 0.14)	0.06 (−0.003, 0.11)	0.06 (0.0004, 0.11)*
Adjusted R2	0.46	0.30	0.37	0.40
Overall model F-test	p < 0.001	p < 0.001	p < 0.001	p < 0.001

^aPST: Processing Speed Test

^bCST: Contrast Sensitivity Test; Model with square of CST as outcome

^cMDT: Manual Dexterity Test; Model with inverse of MDT as outcome

^dWST: Walking Speed Test; Model with square root of WST as outcome

Fully standardized beta coefficients (95% CI) derived from an ordinary least squares linear regression method are reported for variables included in multivariate final model. For a 1.0 increase in standard deviation of an independent variable, holding the other independent variables at their mean, the outcome (dependent variable) changes by the fully standardized coefficient number of standard deviations from its mean.

“--” indicates exclusion of a variable from the final NPT model being described in that column

^*indicates statistical significance (p < 0.05) of a variable in final multivariate model