Table 2.
Biochemical characteristics.
| Dulaglutide group (n = 16) | Glargine group (n = 9) | t | p | |||
|---|---|---|---|---|---|---|
| Fasting blood glucose | Baseline | 10.26 ± 2.84 | 10.72 ± 2.34 | −0.418 | 0.68 | |
| (mmol/L) | 52w | 8.21 ± 1.70 | 6.92 ± 1.60 | 1.85 | 0.077 | |
| HbA1c (%) | Baseline | 8.65 ± 1.57 | 8.73 ± 0.64 | −0.186 | 0.854 | |
| 52w | 7.16 ± 1.17 | 7.40 ± 1.12 | −0.507 | 0.617 | ||
| Total amylase (U/L) | Baseline | 69.44 ± 26.80 | 64.78 ± 17.35 | 0.467 | 0.645 | |
| 52w | 80.44 ± 29.98 | 59.44 ± 13.71 | 1.974 | 0.061 | ||
| Pancreatic enzymes | Baseline | 29.00 ± 7.91 | 28.22 ± 9.85 | 0.216 | 0.831 | |
| (U/L) | 52w | 30.50 (28.25, 37.50) | 24.00 (20.00, 31.00) | −2.212 | 0.026 | |
| Lipase (U/L) | Baseline | 43.94 ± 11.60 | 41.44 ± 14.15 | 0.477 | 0.638 | |
| 52w | 50.50 (38.50, 59.00) | 37.00 (24.00, 55.50) | −1.728 | 0.087 | ||
| Cholesterol (mmol/L) | Baseline | 4.81 ± 1.04 | 4.67 ± 1.05 | 0.324 | 0.749 | |
| 52w | 4.68 ± 1.10 | 4.79 ± 1.35 | −0.221 | 0.827 | ||
| HDL-cholesterol (mmol/L) | Baseline | 1.24 ± 0.21 | 1.31 ± 0.34 | −0.654 | 0.52 | |
| 52w | 1.21 ± 0.28 | 1.13 ± 0.34 | 0.602 | 0.553 | ||
| LDL-cholesterol (mmol/L) | Baseline | 2.82 ± 0.81 | 2.54 ± 1.02 | 0.768 | 0.45 | |
| 52w | 2.68 ± 0.87 | 2.27 ± 0.80 | 1.168 | 0.255 | ||
| Triglyceride (mmol/L) | Baseline | 1.64 ± 0.87 | 1.97 ± 1.63 | −0.655 | 0.519 | |
| 52w | 1.57 (0.88, 2.45) | 1.50 (0.92, 5.866) | −0.142 | 0.901 | ||
| Calcitonin (ng/L) | Baseline | 2.24 ± 0.85 | 2.57 ± 0.73 | −0.954 | 0.35 | |
| 52w | 2.13 ± 0.53 | 2.11 ± 0.33 | 0.103 | 0.919 | ||
| Change | 0 (0, 0) | −0.30 (−0.70, 0) | −2.074 | 0.052 | ||
| White blood count (∗109/l) | Baseline | 6.36 ± 1.42 | 5.84 ± 1.37 | 0.889 | 0.383 | |
| 52w | 6.54 ± 1.48 | 6.19 ± 1.03 | 0.634 | 0.532 | ||
| Haemoglobin (g/L) | Baseline | 149.63 ± 11.77 | 139.89 ± 9.69 | 2.106 | 0.046∗ | |
| 52w | 147.63 ± 13.57 | 139.33 ± 10.71 | 1.573 | 0.129 | ||
| Haematocrit (g/L) | Baseline | 0.45 ± 0.04 | 0.42 ± 0.03 | 2.167 | 0.041∗ | |
| 52w | 0.45 ± 0.04 | 0.42 ± 0.03 | 1.706 | 0.102 | ||
| Red blood count | Baseline | 4.91 ± 0.35 | 4.46 ± 0.50 | 2.65 | 0.014 ∗ | |
| (∗1012/l) | 52w | 4.88 ± 0.39 | 4.52 ± 0.42 | 2.16 | 0.041 | |
| Platelet count (∗109/L) | Baseline | 207.63 ± 68.46 | 180.11 ± 40.20 | 1.266 | 0.218 | |
| 52w | 212.06 ± 59.10 | 195.33 ± 30.66 | 0.931 | 0.361 | ||
| Blood urea nitrogen | Baseline | 5.51 ± 1.34 | 5.55 ± 1.17 | −0.078 | 0.938 | |
| (mmol/L) | 52w | 5.42 ± 1.19 | 5.43 ± 1.68 | −0.021 | 0.984 | |
| Creatinine (μmol/L) | Baseline | 73.50 ± 15.48 | 65.56 ± 12.51 | 1.314 | 0.202 | |
| 52w | 73.06 ± 16.34 | 66.78 ± 14.23 | 0.965 | 0.345 | ||
| Alanine aminotransferase | Baseline | 24.25 ± 13.93 | 17.67 ± 3.35 | 1.8 | 0.089 | |
| (U/L) | 52w | 21.00 (15.25, 36.50) | 22.00 (14.50, 35.50) | −0.142 | 0.901 | |
| Glutamate aminotransferase | Baseline | 20.38 ± 5.84 | 16.78 ± 4.21 | 1.62 | 0.119 | |
| (U/L) | 52w | 21.50 (18.00, 27.00) | 23.00 (17.50, 25.50) | −0.199 | 0.857 | |
| Microalbumin | Baseline | 22.50 (16.00, 52.25) | 30.00 (11.00, 70.50) | −0.085 | 0.944 | |
| (mg/L) | 52w | 26.00 (9.25, 47.25) | 41.00 (9.50, 61.50) | −0.538 | 0.607 | |
| Microalbumin/creatinine | Baseline | 2.70 (1.13, 6.85) | 3.80 (1.15, 12.45) | −0.566 | 0.588 | |
| (mg/g) | 52w | 3.30 (0.78, 4.55) | 4.60 (1.25, 6.55) | −1.076 | 0.295 | |
| Fasting insulin (nmol/L) | Baseline | 8.75 (5.30, 12.68) | 7.90 (6.00, 14.00) | −0.113 | 0.923 | |
| Fasting C-peptide (nmol/L) | Baseline | 0.52 ± 0.31 | 0.41 ± 0.20 | 0.888 | 0.384 | |
| HOMA-IR (%) | Baseline | 0.93 ± 0.35 | 0.96 ± 0.38 | −0.185 | 0.855 | |
HOMA-IR: homeostatic model assessment of insulin resistance.