FIG 2.
Genomic landscape of GPR161-associated medulloblastoma. (A) Germline GPR161 mutations in patients with MB. (B) Demographic and molecular characteristics of GPR161-associated MB. (C) Age at diagnosis across pediatric patients with pathogenic germline mutations in MBSHH predisposition genes. (D) Frequency of pathogenic germline mutations in pediatric MBSHH. (E) Frequency of germline GPR161 mutations in retrospective and prospective pediatric MBSHH cohorts. (F) Frequency of somatic 1p/1q LOH events in MBSHH tumors and association between 1q LOH and GPR161 mutation status. LOH, loss of heterozygosity; MB, medulloblastoma; Mut, mutant; SHH, sonic hedgehog; WT, wild type.