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HCN2 channel expression in L4-L5 ipsilateral spinal dorsal horns was increased significantly after SNI and was decreased after treatment with an intrathecal injection of ZD-7288 and si-HCN2. Data are shown as the mean ± SD. ***P<0.001 vs. Sham group; ##P<0.01, ###P<0.001 vs. SNI group; $$P<0.01 vs. SNI+ZD-7288 group.
