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. 2019 Jan 1;12(1):154–163.

Figure 2.

Figure 2

Inhibition of HCN2 channels significantly increased the MWT and PWL in SNI mice. The paw mechanical withdrawal threshold (MWT, A and C) and the paw withdrawal thermal latency (PWL, B and D) decreased after SNI in mice. The intrathecal injection of ZD-7288 increased the MWT (A) and PWL (B). Pre-treatment with si-HCN2 recovered the decreased MWT (C) and PWL (D) after SNI. Data are shown as the means ± SD. *P<0.05, **P<0.01, ***P<0.001 vs. Sham group; #P<0.05, ##P<0.01, ###P<0.001 vs. SNI group.