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. 2019 Jan 1;12(1):229–240.

Figure 3.

Figure 3

miR-17-5p suppressed PTEN/AKT signaling pathway. A. The 3’ UTR of PTEN matched with the recognition site of miR-17-5p. The seed sequence is marked in red. B. The plasmids with the 3’ UTR of PTEN (3’ UTR), the mutated 3’ UTR regions (mut1, mut2 and mut3) or the vehicle (con) were co-transfected into NPC cells with an miR-17-5p mimic or control respectively. 24 h after transfection, luciferase activity was determined (n = 5). C and D. The mRNA and protein levels of PTEN were measured after miR-17-5p overexpression (n = 5). E. The activation of the AKT signal was detected by western blot (n = 5). *: P < 0.05.