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. 2019 Dec 25;25:9963–9972. doi: 10.12659/MSM.918597

Figure 2.

Figure 2

Effect of naringin on the nucleus pulposus (NP) cells matrix metalloproteinases (MMP-3, 13, ADAMTS-4, 5, Agg, and Col II). (A, D) The picture of western blots showing protein expressions of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, Agg, and Col II treated by IL-1β and different concentrations of naringin (0.4, 0.8, 1.2, and 1.6 μM) for 24 hours in NP cells. (B, E) Western blot analysis on the protein levels of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, Agg, and Col II in NP cells stimulated by IL-1β and treated naringin for 24 hours, respectively. * Versus control, * P<0.05, ** P<0.01; # versus IL-1β, # P<0.05, ## P<0.01. (C, F) qPCR result showed the mRNA level of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, Agg, and Col II in NP cells stimulated with IL-1β and treated naringin for 24 hours, respectively. * Versus control, * P<0.05, ** P<0.01; # versus IL-1β, # P<0.05, ## P<0.01.