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ERK1/2 is involved in NOTCH1 knock-down mediated repression of cell proliferation. (A) The expressions of ERK1/2 and p-ERK1/2 in control cells and NOTCH1 knock-down cells were detected by western blotting. GAPDH was used as an internal control. (B, C) AGS control cells (Vec) as well as cells with NOTCH1 knock-down (shN1-3) were treated with DMSO or MEK1/2 inhibitor U0126 at different concentration (10 μM and 20 μM). The effects of U0126 on cell growth were determined by CCK-8 assays.
