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. 2019 Dec 11;14(1):159–179. doi: 10.1002/1878-0261.12595

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© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The RSK1 signature is enriched in grade IV gliomas. (A,B) GSVA scores for the enrichment in RSK1 signature (signRSK1) were obtained for gliomas of different grades from (A) TCGA and (B) Gravendeel datasets. NT = nontumor. The number of samples for each grade is indicated in parentheses. (C,D) Graphs showing the RSK1 mRNA levels for gliomas of different grades from (C) TCGA and (D) Gravendeel datasets. (E–G) Overall survival plots for (E) grade III (TCGA), (F) grade III (Gravendeel), and (G) grade II (TCGA) gliomas, comparing signRSK1^enriched vs. signRSK1^{underrepresented}. The number of samples is indicated in parentheses.