Table 2.

Putative KLK14 substrates and cleavage sites identified by TAILS. The list of putative KLK14 substrates identified in TAILS analysis are summarized. Indicated are: UniProt accession; gene symbol; protein description; position of cleavage site (P1 residue, *); Log2(ratio iKLK14/imKLK14), and the cellular location of the protein according to IPA. Proteins were classified in terms of their function according to available literature.

	Accession	Symbol	Protein description	P1	Log2 (FC)	Cellular location
Peptidases and peptidase regulators	http://www.uniprot.org/uniprot/P01034	CST3	Cystatin‐C	R 34	5.6	Extracellular space
	http://www.uniprot.org/uniprot/O14672	ADAM10	Disintegrin and metalloproteinase domain‐containing protein 10	R 448	2.2	Plasma membrane
	http://www.uniprot.org/uniprot/P00734	F2	Prothrombin	R 560	5.0	Extracellular space
	http://www.uniprot.org/uniprot/P07288	KLK3	Prostate‐specific antigen	R 24	2.7	Extracellular space
	http://www.uniprot.org/uniprot/Q9P0G3	KLK14	Kallikrein‐14	K 40	2.4	Extracellular space
				R 197	4.9
				R 141	3.8
	http://www.uniprot.org/uniprot/Q15113	PCOLCE	Procollagen C‐endopeptidase enhancer 1	R 149	2.3	Extracellular space
	http://www.uniprot.org/uniprot/P29122	PCSK6	Proprotein convertase subtilisin/kexin type 6	R 825	2.5	Extracellular space
	http://www.uniprot.org/uniprot/Q9Y5Y6	ST14	Suppressor of tumorigenicity 14 protein	R 614	4.0	Plasma membrane
				R 208	3.7
	http://www.uniprot.org/uniprot/P10646	TFPI	Tissue factor pathway inhibitor	R 77	4.8	Extracellular space
ECM, proteoglycans, basement membrane constituents	http://www.uniprot.org/uniprot/O00468	AGRN	Agrin	R 261	3.3	Plasma membrane
				R 451	2.4
				R 541	3.7
				R 782	4.9
				R 1810	2.5
				R 1839	2.0
				K 1863	3.5
				R 1964	3.5
	http://www.uniprot.org/uniprot/O15230	LAMA5	Laminin subunit alpha‐5	R 849	4.4	Extracellular space
				R 3582	3.9
	http://www.uniprot.org/uniprot/P55268	LAMB2	Laminin subunit beta‐2	R 44	4.1	Extracellular space
				R 907	2.2
	http://www.uniprot.org/uniprot/P11047	LAMC1	Laminin subunit gamma‐1	R 663	3.8	Extracellular space
	http://www.uniprot.org/uniprot/P31431	SDC4	Syndecan‐4	R 22	4.4	Plasma membrane
	http://www.uniprot.org/uniprot/Q9H3U7	SMOC2	SPARC‐related modular calcium‐binding protein 2	R 94	3.2	Extracellular space
Regulators of cell adhesion and morphology	http://www.uniprot.org/uniprot/O94910	ADGRL1	Adhesion G protein‐coupled receptor L1	R 37	4.4	Plasma membrane
	http://www.uniprot.org/uniprot/Q13740	ALCAM	CD166 antigen OS = Homo sapiens	R 344	3.7	Plasma membrane
	http://www.uniprot.org/uniprot/O94985	CLSTN1	Calsyntenin‐1	R 372	3.8	Plasma membrane
				R 665	6.3
				K 791	3.1
	http://www.uniprot.org/uniprot/Q9BQT9	CLSTN3	Calsyntenin‐3	R 151	3.5	Plasma membrane
	http://www.uniprot.org/uniprot/P98153	DGCR2	Integral membrane protein DGCR2/IDD	R 90	2.4	Plasma membrane
	http://www.uniprot.org/uniprot/Q02487	DSC2	Desmocollin‐2	R 190	2.6
	http://www.uniprot.org/uniprot/Q14126	DSG2	Desmoglein‐2	K 215	5.2	Plasma membrane
				K 468	3.5
	http://www.uniprot.org/uniprot/O15394	NCAM2	Neural cell adhesion molecule 2	R 118	6.6	Plasma membrane
				R 336	4.0
	http://www.uniprot.org/uniprot/Q92859	NEO1	Neogenin	R 35	2.9	Plasma membrane
	http://www.uniprot.org/uniprot/O15031	PLXNB2	Plexin‐B2	R 807	2.9	Plasma membrane
	http://www.uniprot.org/uniprot/P10586	PTPRF	Receptor‐type tyrosine‐protein phosphatase F	R 282	4.4	Plasma membrane
				R 355	4.5
				R 585	3.2
				R 702	2.6
	http://www.uniprot.org/uniprot/Q99985	SEMA3C	Semaphorin‐3C	R 55	2.2	Extracellular space
	http://www.uniprot.org/uniprot/Q9BUD6	SPON2	Spondin‐2	R 249	2.5	Extracellular space
	http://www.uniprot.org/uniprot/P50570	DNM2	Dynamin‐2	R 510	3.1	Plasma membrane
	http://www.uniprot.org/uniprot/Q969P0	IGSF8	Immunoglobulin superfamily member 8	R 94	3.7	Plasma membrane
Growth factors/ growth factor & hormone receptors and coreceptors	http://www.uniprot.org/uniprot/Q9NYQ6	CELSR1	Cadherin EGF LAG seven‐pass G‐type receptor 1	R 756	2.6	Plasma membrane
	http://www.uniprot.org/uniprot/Q9UHF1	EGFL7	Epidermal growth factor‐like protein 7	R 184	5.5	Extracellular space
	http://www.uniprot.org/uniprot/Q99988	GDF15	Growth/differentiation factor 15	R 217	4.6	Extracellular space
				R 107	3.9
				R 263	3.1
	http://www.uniprot.org/uniprot/Q8N2S1	LTBP4	Latent‐transforming growth factor beta‐binding protein 4	R 336	3.6	Extracellular space
	http://www.uniprot.org/uniprot/P46531	NOTCH1	Neurogenic locus notch homolog protein 1	R 207	4.4	Plasma membrane
Others	http://www.uniprot.org/uniprot/P02765	AHSG	Alpha‐2‐HS‐glycoprotein	K 131	6.1	Extracellular space
	http://www.uniprot.org/uniprot/P08758	ANXA5	Annexin A5	R 6	4.0	Plasma membrane
	http://www.uniprot.org/uniprot/Q13308	PTK7	Inactive tyrosine‐protein kinase 7	R 92	2.6	Plasma membrane
				R 226	2.7
	http://www.uniprot.org/uniprot/Q9ULF5	SLC39A10	Zinc transporter ZIP10	R 41	1.9	Extracellular space
	http://www.uniprot.org/uniprot/P08294	SOD3	Extracellular superoxide dismutase [Cu‐Zn]	R 176	2.7	Extracellular space
	http://www.uniprot.org/uniprot/P5282	STC1	Stanniocalcin‐1	R 33	2.2	Extracellular space
	http://www.uniprot.org/uniprot/P02786	TFRC	Transferrin receptor protein 1	R 109	2.1	Plasma membrane