Table 2. Univariate and multivariate Cox regression analyses of the risk score and other clinicopathological factors in training set and validation set.
HR, Hazard ratio; 95%CI, 95% confidence interval.
| Variables | Training set (n = 456) | Validation set (n = 159) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||||
| HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | ||
| Age group (Median) | Younger vs. old | 0.278 | 0.184–0.420 | 1.3E−09 | 0.274 | 0.179–0.418 | 2.21E−09 | 0.817 | 0.530–1.261 | 0.363 | 1.051 | 0.654–1.691 | 0.837 |
| Sex | Male vs. Female | 1.043 | 0.721–1.509 | 0.823 | 1.081 | 0.743–1.572 | 0.686 | 0.641 | 0.416–0.989 | 0.044 | 0.651 | 0.412–1.028 | 0.066 |
| Grade | G3 vs. G2 | 3.301 | 2.196–4.963 | 9.3E−09 | 2.49 | 1.568–3.953 | 0.00011 | 3.590 | 2.292–5.625 | 2.4E−08 | 3.799 | 2.205–6.545 | 0.00000151 |
| Molecular therapy | Yes vs. No | 1.366 | 0.924–2.018 | 0.117 | 0.893 | 0.578–1.379 | 0.608 | / | / | / | / | / | / |
| Chemoterapy | Yes vs. No | / | / | / | / | / | / | 2.216 | 1.409–3.485 | 0.00057 | 1.041 | 0.614–1.765 | 0.881 |
| Risk level | Low vs. High | 0.188 | 0.118–0.299 | 2.1E−12 | 0.198 | 0.120–0.325 | 1.68E−10 | 0.246 | 0.153–0.394 | 5.7E−09 | 0.415 | 0.251–0.688 | 0.000653 |
| IDH_status | Wildtype vs. Mutant | / | / | / | / | / | / | 2.496 | 1.582–3.937 | 8.4E−05 | 0.995 | 0.600–1.650 | 0.983 |
| 1p19q_status | Non_codel vs. Codel | / | / | / | / | / | / | 6.554 | 3.358–12.790 | 3.6E−08 | 4.566 | 2.215–9.414 | 0.0000388 |
| Radiation therapy | Yes vs. No | 1.996 | 1.278–3.118 | 0.00236 | 0.814 | 0.488–1.358 | 0.43 | 0.475 | 0.262–0.861 | 0.0141 | 0.524 | 0.277–0.990 | 0.046 |