Table 1.
Study Sample: Demographics, Clinical Variables, and Peripheral Blood Mononuclear Cell Oxidative Phosphorylation Protein Levels
| Characteristics | |
|---|---|
| N | 28 |
| Age (years) | 52.5 ± 7.2 |
| Sex (male) | 24 (85.7%) |
| Race/ethnicity (Caucasian) | 13 (46.4%) |
| Years since HIV diagnosis | 20.5 ± 7.0 |
| Years on cART | 18.1 ± 5.9 |
| CD4 count (cells/mm3) | 501 ± 203 |
| Nadir CD4 count (cells/mm3) | 176 ± 144 |
| Undetectable plasma HIV RNA (<50 copies/mL) | 23 (82.1%) |
| PBMC OXPHOS Complex 1 protein level (OD/μg × 103) | 33.8 ± 9.4 |
| PBMC OXPHOS Complex 4 protein level (OD/μg × 103) | 27.6 ± 5.6 |
| Ever used AZT, d4T, or ddI | 18 (64.3%) |
| Ever used any druga | 25 (89.3%) |
| Marijuana use (lifetime frequency)b | |
| Never | 0 (0%) |
| 1–10 times | 7 (28%) |
| >10 times | 18 (72%) |
| Methamphetamine use (lifetime frequency)b | |
| Never | 15 (60%) |
| 1–10 times | 3 (12%) |
| >10 times | 7 (28%) |
| Use of stimulants (lifetime frequency)b | |
| Never | 20 (80%) |
| 1–10 times | 2 (8%) |
| >10 times | 3 (12%) |
| Alcohol usec | |
| Never | 11 (42.3%) |
| Sometimes (≤4 times/month) | 11 (42.3%) |
| Frequently (>2 times/week) | 4 (15.4%) |
Data are given as mean ± SD for continuous variables and n (%) for categorical variables.
a
Drugs include marijuana, cocaine, crack, stimulants, phencyclidine, methamphetamine, heroin, lysergic acid diethylamide, ecstasy, nitrates, glue, ketamine, methadone, barbiturates, painkillers, and sedatives.
b
n = 25.
c
n = 26.
AZT, azidothymidine; cART, combination antiretroviral therapy; d4T, stavudine; ddI, didanosine; OD, optical density; OXPHOS, oxidative phosphorylation; PBMCs, peripheral blood mononuclear cells; SD, standard deviation.