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. 2019 Dec 26;25:10008–10015. doi: 10.12659/MSM.918172

Figure 5.

Figure 5

The 3′-UTR of SIRT1 is a target of miR-506. (A) Illustration of the conserved binding motifs of miR-506 in the 3′-UTR of WT SIRT1. (B) DLRGA contained the wild-type (WT) and mutant-type (MU) 3′-UTR of human SIRT1 after miR-506 mimic transfection. Luciferase activity was normalized to β-galactosidase activity. (C) Q-PCR and (D) WB analyses determined the expression of SIRT1 mRNA in LPS-treated DPSCs transfected with miR-506 or NC inhibitor. Data are represented as means±SD. * P<0.05; *** P<0.001.