TABLE 1.

JMHW and HRS Diagnostic Criteria for CS (29,30)

JMHW	HRS
Histologic diagnosis group	Histologic diagnosis from myocardial tissue
CS confirmed by EMB, and histologic or clinical diagnosis of extraCS	Noncaseating granuloma on EMB with no alternative cause identified
Clinical diagnosis group	Clinical diagnosis
Histologic or clinical diagnosis of extraCS and	Probable diagnosis of CS exists if
Two or more major criteria or	There is histologic diagnosis of extraCS* and
One major criterion and two or more minor criteria	One or more of the following is present:
Major criteria	Cardiomyopathy or atrioventricular block responsive to immunosuppressive treatment*
Advanced atrioventricular block	Unexplained reduced LVEF (<40%)
Basal thinning of intraventricular septum	Unexplained ventricular tachycardia
67Ga uptake in heart	Mobitz II second- or third-degree heart block
Depressed LVEF (<50%)	Patchy 18F-FDG uptake on cardiac PET consistent with CS*
Minor criteria	Late gadolinium enhancement on cardiac MRI consistent with CS
Electrocardiography: ventricular tachycardia, PVCs, RBBB, abnormal axis, abnormal Q wave	Cardiac 67Ga uptake and
Echocardiography: structural or wall motion abnormality	Exclusion of other causes of cardiac manifestations
Nuclear medicine: perfusion defect, 201Tl, 99mTc*
Cardiac MRI: late gadolinium enhancement
EMB: moderate fibrosis or monocyte infiltration

^*Significant difference between JMHW and HRS criteria.

PVC = premature ventricular contractions; RBBB = right bundle branch block.