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. Author manuscript; available in PMC: 2020 Jan 6.
Published in final edited form as: Nat Rev Immunol. 2015 Sep 21;15(10):643–654. doi: 10.1038/nri3889

Figure 4 |. T cell receptor (TCRs) that function through co-recognition.

Figure 4 |

This figure shows examples of αβ TCRs14, 72, 73 and a γδ TCR16 that make direct contact with a hybrid surface formed by the antigen-presenting molecule and the antigen as it protrudes from the groove. The natural killer T (NKT) cell TCR interacts with CD1d displaying α-galactosylceramide (αGalCer); the mucosal-associated invariant T (MAIT) cell TCR interacts with MHC class I-related protein (MR1) displaying 5-oxopropylideneamino-6-D-ribitylaminouracil; the ELS4 TCR interacts with the MHC class I molecule HLA-B35 displaying an Epstein-Barr virus (EBV)-derived peptide; and the 9C2 γδTCR interacts with CD1d displaying αGalCer. The TCR footprint is shown in red in the lower panels. In these four examples the TCR contacts both the antigen-presenting molecule and the bound ligand, so these represent the mechanisms of TCR co-recognition.