Table 1 |.
Human invariant T cell types that recognize non-polymorphic antigen-presenting molecules
| CD1b | CD1b | CD1c | CD1d | MR1 | MHC | |
|---|---|---|---|---|---|---|
| Designation | GEM T cells | LDN5-like cells | NKT cells | MAIT cells | ||
| Antigen | Glucose monomycolate | Glucose monomycolate | Phospho-mycoketide | αGalCer & others | vitamin B metabolites | Peptides |
| TCR α chain Variable gene Joining gene CDR3 length | Invariant TRAV1-2 TRAJ9 Uniform |
Biased TRAV17 Uniform |
Diverse Variable |
Invariant TRAV10 TRAJ18 Uniform |
Invariant TRAV1-2 TRAJ33 Uniform |
Diverse All All Variable |
| TCR β chain Variable gene CDR3 length | Biased TRBV6-2 Variable |
Biased TRBV4-1 Variable |
Biased TRBV7-9 TRBV7-8 Variable |
Biased TRBV25-1 Variable |
Biased TRBV20-1 TRBV6-1 Variable |
Diverse All Variable |
| Intradonor conservation | High | High | High | High | High | Low |
| Interdonor conservation | High | High | High | High | High | Low |