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. Author manuscript; available in PMC: 2020 Mar 13.
Published in final edited form as: J Am Chem Soc. 2019 Feb 27;141(10):4398–4405. doi: 10.1021/jacs.8b13453

Figure 1: PQQ cofactor biosynthesis.

Figure 1:

a) A biosynthetic schematic. Steps in blue are derived from the analog studies presented herein. A protease, to convert the peptide-bound cross-linked Glu and Tyr to the substrate of PqqB, is inferred from the present study but not yet characterized. b) Structures of the PqqB substrate analog Cys-Tyr and catalytic intermediate analog Cys-DOPA.