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. Author manuscript; available in PMC: 2020 Mar 13.
Published in final edited form as: J Am Chem Soc. 2019 Feb 27;141(10):4398–4405. doi: 10.1021/jacs.8b13453

Figure 7. Proposed reactions of PqqB.

Figure 7.

a) A proposed mechanism for the PqqB reaction with the Glu-Tyr diamino acid. b) Our postulated mechanism for the PqqB-catalyzed hydroxylation of Cys-DOPA. The X-ray structure of the Zn2+-PqqB-Cys-DOPA complex (Fig. 5), in which Asp is either on or off metal, is compatible with the illustrated mobility of the Asp ligand within intermediate (2). An alternative mechanism is presented for consideration in Fig. S10.