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. 2019 Sep 27;173(1):144–155. doi: 10.1093/toxsci/kfz208

Figure 2.

Figure 2.

Brain (top, µg/g tissue) and blood (bottom, ng/ml) Mn concentrations in rats at 24, 66, and approximately 500 days of age. Whole brain tissue was sampled for the brain Mn determinations. Note the difference in magnitude of Mn levels as a function of age and the corresponding comparisons to control values. Group N’s for brain tissue were 11–16 at postnatal day (PND) 24, 14–17 at PND 66, and 12–17 at PND approximately 500. ****p < .0001, ***p < .001, **p < .01, and *p < .05 compared with control values at the same age. The blood Mn values of each group at 66 days of age are significantly greater than those of the same group at approximately 500  days of age by Sidak’s multiple comparisons post hoc test; this is true for brain Mn concentrations only for the Early Life 50 group. Group N’s for blood samples were 11–17 at PND 24, 13–17 at PND 66, and 15–21 at PND approximately 500.