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. 2019 Oct 8;173(1):86–99. doi: 10.1093/toxsci/kfz211

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com

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Figure 2. — Structure of the generic life-stage PBPK model for pyrethroids in humans. QLIVGI, QLIVH, QRP, QSP, QFAT, and QBRN refer to plasma flow to each tissue compartment. QLIV is the sum of QLIVGI and QLIVH. QAlv refers to the alveolar ventilation rate. Brain, fat, and slowly perfused tissue compartments are described as diffusion-limited tissues (the dotted lines represent the separation between tissue [intracellular space] and blood tissue [extracellular space]), whereas all other tissue compartments are described as flow limited.