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. 2019 Nov 1;19(1):78–100. doi: 10.1074/mcp.RA119.001594

Fig. 4.

Fig. 4.

Distribution of exProteins common to autologous blood and semen. A, Four- and three-way Venn diagrams for identification of protein compartmentalization in exosomes and exosome-free plasma within each body-fluid for each donor, and for identification of common proteins to every compartment in healthy and HIV-infected groups. B, Two-way Venn analysis identifying proteins common to blood and semen after filtering out variabilities from the donor, clinical status, and body-fluid type. The common proteins are in large and bold font for the four- three- and two- way Venns. C, Heatmap showing enrichment pattern across four variables—body-fluid type, clinical group, compartmentalization, and donor for the 8 common proteins in b. D, Quantitation of the mean difference in enrichment score for the 8 common proteins. Deferentially present proteins were determined using the 2-way ANOVA test by controlling the FDR (Benjamini and Hochberg). Adjusted p values are shown in supplemental Table S2. Differences were significant when adjusted p value < 0.05. E, Protein-protein interaction (PPI) network analyses of CLU using STRING database (1, 2) analyzed February 8, 2019. f, Western blotting of CLU in BE and SE from HIV- and HIV+ samples.