Table I. Functional enrichments in CLU protein-protein interaction network as determined by STRING analysis (Top 5).

	Biological process (GO)	Count in gene set	FDR
	Regulation of proteolysis	9	1.25e-08
2	Humoral immune response	7	1.46E-08
3	Platelet degranulation	6	2.04E-08
4	Complement activation, classical pathway	4	1.40E-06
5	Regulation of protein activation cascade	4	3.68e-06

	Molecular function (GO)	Count in gene set	FDR
1	Receptor activator activity	2	0.0029
2	Growth factor receptor binding	3	0.0033
3	Low-density lipoprotein particle receptor binding	2	0.0035
4	Heparin binding	3	0.0035
5	Chemoattractant activity	2	0.0037

	Cellular component (GO)	Count in gene set	FDR
1	Platelet alpha granule lumen	6	2.12e-10
2	Secretory granule lumen	7	7.39e-09
3	Extracellular region	11	7.59e-09
4	Membrane attack complex	3	4.42e-07
5	Extracellular space	7	1.07e-05

	KEGG pathways	Count in gene set	FDR
1	Complement and coagulation cascades	4	4.34e-06
2	Systemic lupus erythematosus	4	4.46e-06
3	Prion diseases	3	1.46e-05
4	Amoebiasis	3	0.00022
5	Focal adhesion	3	0.0015