Table.

Clinical Details of the Families Segregating the ARL3 Variant

ID	Disease Status	ARL3 Genotype	Age (y)	Age of Onset of Symptoms	Best-Corrected Visual Acuity: OS;OD	Refraction	Color Vision	Photophobia: OS/OD	ERG Status
LUSG-03
IV:4	Normal	WT/M	8	NA	6/6;6/6	0.00	Normal	Neg	Normal rod and cone response
V:3	Normal	WT/M	32	NA	6/6;6/6	0.00	Normal	Neg	Normal rod and cone response
IV:3	Affected	M/M	25	First decade	6/36;6/36	−5.5/−5.5	Normal	++/++	Mildly reduced scotopic amplitudes with normal implicit time, severely reduced photopic amplitudes and very delayed implicit times OU
V:1	Affected	M/M	24	First decade	6/36;6/36	−5.25/−5.50	Impaired	++/++	Normal scotopic, reduced photopic amplitudes (severe OD, moderate OS), delayed implicit times OU
V:5	Affected	M/M	29	First decade	6/60;6/60	−5.75/−5.50	Normal	+/+	Normal scotopic, severely reduced photopic amplitudes OU
V:7	Affected	M/M	44	First decade	6/24;6/24	−6.50/−6.0	Impaired	+/+	Normal scotopic, severely reduced photopic amplitudes OU
LUSG-04
IV:1	Affected	M/M	30	First decade	6/36;6/36	−5.0/−5.0	Normal	+/+	Reduced amplitudes OU
IV:2	Affected	M/M	25	First decade	6/24;6/24	−4.0/−4.75	Normal	+/+	Reduced amplitudes OU
IV:5	Affected	M/M	11	First decade	6/9;6/9	−3.25/−2.50	Impaired	+/+	Moderately reduced photopic amplitudes OU, poor scotopic rod responses but normal scotopic combined responses OU (possibly insufficient dark adaptation time)

M, mutant; NA, not applicable; Neg, negative; WT, wild type.