Table 7. Incremental cost-effectiveness results – base case and sensitivity analysis.
| Analysis | Intravenous
Mean costs (SE) |
Oral
Mean costs (SE) |
Difference (95%
confidence interval) ‡ |
Intravenous
Mean QALYs (SE) |
Oral Mean
QALYs (SE) |
Difference (95%
confidence interval) ‡ |
Incremental
cost per QALY |
|---|---|---|---|---|---|---|---|
| Base case (Multiple
imputation) |
£13,274
(£446) |
£10,534
(£453) |
£2,740
(£1,488 to £3,992) |
0.537
(0.013) |
0.545
(0.015) |
-0.007
(-0.045 to 0.031) |
Oral antibiotics
dominant |
| Complete case | £13,275
(£10,113) |
£10,549
(10,371) |
£2,727
(£1,473 to £3,980) |
0.558
(0.265) |
0.535
(0.300) |
0.023
(–0.036 to 0.081) |
Oral antibiotics
dominant |
| Mean imputation
costs |
£13,141
(£10,036) |
£10,406
(£10,269) |
£2,735
(£1,508 to £3,963) |
0.537
(0.013) |
0.545
(0.015) |
-0.007
(-0.045 to 0.031) |
Oral antibiotics
dominant |
| District Nurse costs
for all missing OPAT types |
£13,274
(£448) |
£10,657
(£463) |
£2,617
(£1,354 to £3,880) |
0.537
(0.013) |
0.545
(0.015) |
-0.007
(-0.045 to 0.031) |
Oral antibiotics
dominant |
| Self-administration
costs for all missing OPAT types |
£13,230
(£442) |
£10,343
(£448) |
£2,887
(£1,656 to £4,118) |
0.537
(0.013) |
0.545
(0.015) |
-0.007
(-0.045 to 0.031) |
Oral antibiotics
dominant |
QALYs, quality-adjusted life years; SE, standard error; OPAT, outpatient parenteral antimicrobial therapy.
‡Difference between arms was calculated using a generalized linear model