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. Author manuscript; available in PMC: 2020 Jan 6.
Published in final edited form as: Sci Transl Med. 2017 Nov 22;9(417):eaag1209. doi: 10.1126/scitranslmed.aag1209

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen.

Fig. 3.

(A) HY-CAR4 and HY-CAR8 expansion in the bone marrow of leukemia-bearing HY+ or HY− mice (n = 5) 7 days after CAR T cell infusion. (B and C) Percent caspase 3/7+ CAR8 and CAR4 cells at 72 hours after infusion. (D and E) Mean fluorescence intensity (MFI) of PD-1 and LAG3 on HY-specific CAR T cells in male (HY+) and female (HY−) recipients day +7 after infusion (**P < 0.01, ****P < 0.0001). (F) Overlaid zebra plots of PD-1 and LAG3 expression of endogenous T cells or HY-CAR4 or HY-CAR8 cells in the presence or absence of HY antigen (one-way ANOVA performed for all comparisons).