Table 1. Clinically relevant substrates of the MDR-related ABC transporters.

Data compiled from [2,94].

Class	Substrate	ABCB1	ABCC1	ABCG2
Vinca alkaloids	Vinblastine	✓	✓
	Vincristine	✓	✓
	Vinorelbine	✓	✓
Anthracyclines	Daunorubicin	✓	✓	✓
	Doxorubicin	✓	✓	✓
	Epirubicin	✓	✓	✓
Epipodophyllotoxins	Etoposide	✓	✓	✓
	Teniposide	✓		✓
Taxanes	Docetaxel	✓
	Paclitaxel	✓
Kinase inhibitors	Dasatinib	✓	✓	✓
	Erlotinib	✓		✓
	Gefitinib	✓		✓
	Imatinib (Gleevec)	✓	✓	✓
	Lapatinib	✓		✓
	Nilotinib	✓	✓	✓
	Sorafenib	✓		✓
	Sunitinib	✓		✓
	Vandetanib		✓	✓
Campthotecins	Irinotecan (CPT-11)	✓	✓	✓
	SN-38	✓	✓	✓
	Arsenite		✓
	AZT			✓
	Bisantrene	✓		✓
	Cisplatin		✓
	Colchicine	✓	✓
	Digoxin	✓
	Flavopiridol			✓
	Methotrexate	✓	✓	✓
	Mitoxantrone	✓		✓
	Saquinivir	✓