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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Reprod Toxicol. 2019 Jul 21;89:145–158. doi: 10.1016/j.reprotox.2019.07.012

Figure 2: Three generation MGR example.

Figure 2:

This example demonstrates that within the MGR study design, there could be 14 treatment groups, which would then need to be multiplied by the number of doses used in the study. Many of the study designs in ToxRefDB have the potential for the addition of interim, recovery, and satellite groups in order to investigate findings of interest. Even though the MGR guideline [33] does not require an F3 generation, many studies will report findings from at least a “first mating” treatment group of the F3 generation.