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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Reprod Toxicol. 2019 Jul 21;89:145–158. doi: 10.1016/j.reprotox.2019.07.012

Figure 3: ToxRefDB general schema with changes made from ToxRefDB v1 to ToxRefDB v2.

Figure 3:

Highlighted in blue are the additions to the generic schema to accommodate the updates and additional features for ToxRefDB v2. These include tables to capture the dose-response, quantitative data; guideline profiles for the inference workflow to determine negative endpoints and effects; UMLS cross-references; and effect groupings for systematically calculating PODs and associated effect levels.