Table 6: Number of datasets in ToxRefDB v2 for BMDS modeling.
Each dataset consists of a chemical-effect pair with all doses, number of test animals, effect values, and variance information if available. The table shows the number of modeled datasets, the BMR used, the number of recommended models, and number of chemicals with a recommended BMD model by type of data. The chemical counts are by data type, as the same chemical can have data in multiple data types. The “total” number of chemicals refers to the total number of chemicals associated with the datasets available for BMDS.
Data type | Number of datasets available for BMDS | Benchmark responses used | Have Recommended BMD Model | Chemicals (n) with a Recommended BMD Model / Total |
---|---|---|---|---|
Cancer | 1 170 | 5% | 1 101 | 243 / 247 |
10% | 1 107 | 246 / 247 | ||
Non-cancer dichotomous | 17 318 | 5% | 16 059 | 609 / 612 |
10% | 16 165 | 611 / 612 | ||
Continuous body/organ weight | 9 268 | 10% relative deviation | 4 151 | 416 / 430 |
Continuous non-body/organ weight | 1 standard deviation | 3 006 | 284 / 300 |