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. 2020 Jan 6;15(1):e0226870. doi: 10.1371/journal.pone.0226870

Table 4. Time to first viral suppression by PL use.

Unadjusted Hazard Ratio (95% CI) N = 37 Adjusted Hazard Ratio1 (95% CI) N = 29
PL Query Response Rate
    Low Ref Ref
    High 1.69 (0.77–3.71) 2.09 (0.64–6.88)

Among patients who were not virally suppressed at baseline, patients were followed from their date of PL enrollment until the first date on which they had a lab value indicating viral suppression (HIV viral load <200 copies/mL) or the date of censoring. Patients were censored for the following reasons: one year with no lab value, death, dropout, study completion, or administrative censoring on September 30, 2017. PL use is updated on a monthly basis and is calculated as the response rate to daily queries. A low query response rate is <48% and a high query response rate is ≥48%. PL use is lagged such that PL use in the month prior to the event of interest or censoring is treated as the exposure; patients who achieved viral suppression within the first month of PL enrollment were therefore considered unexposed and were not included in the analysis.

1Adjusted hazard ratio is adjusted for the following covariates: race (Black non-Hispanic, White non-Hispanic, Hispanic, Other/unknown), education (less than high school, high school or equivalent, greater than high school), and baseline perceived stress (low, moderate, high). Final adjusted model was chosen based on lowest AIC.