Table 1. Effect Sizes and significance levels at varying doses of methacholine for loci identified for AHR on chromosomes 19 and 3.
| Methacholine Dose (mg.ml-1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chromosome | SNP | Exposure | Factor | 0 | 2.5 | 5 | 10 | 20 | 40 |
| 19 | rs51547574 | PBS | *Beta (C allele) | 0.129 | 0.221 | 0.097 | 0.148 | 0.051 | 0.036 |
| **p-value | 1.5x10-5 | 5.6x10-7 | 1.9x10-2 | 3.7x10-4 | 1.9x10-1 | 3.4x10-1 | |||
| 3 | rs30880385 | ΔDEP-PBS | *Beta (T allele) | -0.060 | -0.137 | -0.040 | -0.571 | -0.111 | -0.045 |
| **p-value | 5.5x10-1 | 2.2x10-1 | 7.3x10-1 | 2.5x10-6 | 3.3x10-1 | 7.1x10-1 | |||
*Betas are shown for the indicated effect allele as normal inverse transformed values.
**Genome-wide significant associations are shown in bold.