Fig 3. Functional characterization of G634R MASP-2 proteins.

A. MASP-2 amount was evaluated in plasma of patient/family individuals carrying the G634R mutation (N = 4) as well as in WT individuals (N = 8). Each G634R individual was individually matched with 2 WT individuals having similar MBL levels (B) and the activity of MBL/MASP-2 complexes was determined by ELISA (C). D. Virus neutralization assay on plasma from both G634R and WT individuals. Virus titer determination was based on the presence of cytopathic effects on Vero cells. Statistical analyses were performed using an unpaired Student t-test.