Table 1. Functional annotation analysis of downregulated differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD) datasets using the DAVID tool.
| Term | Count | P Value | Genes | Pop Hits | Fold Enrichment |
|---|---|---|---|---|---|
| hsa04610:Complement and coagulation cascades | 17 | 2,02E-05 | F11, C7, A2M, F10, C5AR1, MASP1, C6, F8, SERPING1, C1QA, C8B, VWF, C1QB, THBD, CFD, PROS1, CPB2 | 69 | 3,423022096 |
| hsa04270:Vascular smooth muscle contraction | 21 | 1,10E-04 | RAMP3, ADCY4, RAMP2, NPR1, PRKCE, PRKG1, MYL9, AGTR1, ACTG2, PRKCQ, PTGIR, GNAQ, ADCY9, GUCY1A2, PLA2G1B, MYH11, CALCRL, PLA2G3, PLA2G5, MYLK, PPP1R14A | 112 | 2,605020492 |
| hsa04514:Cell adhesion molecules (CAMs) | 21 | 0,00103288 | SELP, ITGAL, CLDN18, PTPRM, CADM1, ICAM2, CLDN5, NFASC, CLDN11, HLA-E, CDH5, SIGLEC1, CD34, ITGA8, ESAM, JAM2, JAM3, NEGR1, SELE, SELPLG, SPN | 132 | 2,210320417 |
| hsa04080:Neuroactive ligand-receptor interaction | 32 | 0,00245857 | F2RL3, THRB, LEPR, PTH1R, FPR1, GRIN3B, FPR2, VIPR1, APLNR, AGTR1, EDNRB, AGTR2, PTGIR, S1PR1, NMUR1, S1PR4, CNR1, P2RY1, S1PR5, CALCRL, GHR, GRID1, C5AR1, PTGER4, PTGFR, ADRB2, ADRB1, P2RX1, SSTR1, GRIA1, P2RY14, CTSG | 256 | 1,736680328 |
| hsa04614:Renin-angiotensin system | 6 | 0,0055758 | AGTR1, ACE, AGTR2, MME, CPA3, CTSG | 17 | 4,903567985 |
| hsa02010:ABC transporters | 9 | 0,0117617 | ABCA8, ABCC9, ABCA9, ABCB1, CFTR, ABCA3, ABCG1, ABCA6, ABCG2 | 44 | 2,841840537 |
| hsa04670:Leukocyte transendothelial migration | 16 | 0,02073563 | ITGAL, CLDN18, NCF2, NCF1, CLDN5, CLDN11, CXCL12, CDH5, MYL9, CYBB, ESAM, PIK3R5, RAPGEF4, JAM2, JAM3, PIK3R1 | 118 | 1,883856627 |
| hsa03320:PPAR signaling pathway | 11 | 0,02420575 | LPL, CD36, CYP27A1, SORBS1, OLR1, PPARG, RXRG, FABP4, SCD5, ACADL, FABP5 | 69 | 2,21489665 |
| hsa04062:Chemokine signaling pathway | 22 | 0,02578677 | ADCY4, CCL2, FGR, NCF1, PREX1, HCK, CXCL3, CXCL2, CXCR1, GNG11, CXCR2, CXCL12, CCL14, CCL23, PPBP, ADCY9, ARRB1, RASGRP2, CX3CR1, PIK3R5, GRK5, PIK3R1 | 187 | 1,634522662 |
| hsa04060:Cytokine-cytokine receptor interaction | 28 | 0,03410983 | CSF3, ACVRL1, CCL2, PDGFB, CXCL3, LEPR, CXCL2, BMPR2, CXCR1, CXCR2, TNFSF13, TNFSF12, IL7R, CXCL12, CCL23, PLEKHO2, FIGF, GHR, IL18R1, IL6, BMP2, FLT4, TGFBR2, LIFR, CCL14, PPBP, IL20RA, CX3CR1, IL3RA | 262 | 1,484795395 |
| hsa05020:Prion diseases | 7 | 0,0361229 | C1QA, EGR1, C1QB, C8B, C7, IL6, C6 | 35 | 2,778688525 |
| hsa00590:Arachidonic acid metabolism | 9 | 0,04474724 | ALOX15, PTGIS, PTGDS, GPX3, PLA2G1B, LTC4S, ALOX5, PLA2G3, HPGDS, PLA2G5 | 56 | 2,232874707 |
| hsa04350:TGF-beta signaling pathway | 12 | 0,04546484 | BMP2, SMAD9, ACVRL1, CDKN2B, ZFYVE9, SMAD6, LEFTY2, TGFBR2, BMPR2, ID4, DCN, ID3 | 87 | 1,916336914 |
The results revealed that downregulated consistent DEGs indicated the genes that were associated with the top four pathways: “Complement and coagulation cascades”, “Vascular smooth muscle contraction”, “Cell adhesion molecules (CAMs)” and, “Neuroactive ligand-receptor interaction”.