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. 2019 Dec 31;10(68):7198–7219. doi: 10.18632/oncotarget.27319

Figure 10. Propionibacterium freudenreichii WT strain reduces the pro-inflammatory cytokine IL-12 production during 5-FU-induced mucositis .

Figure 10

The secreted levels of (A) IL-10, (B) IL-12, (C) IL-1β, and (D) IL-10/IL-12 ratio were determined in the supernatant of homogenized mice ileum tissue using ELISA. Mice consumed water, YEL culture medium (YEL control), a YEL culture of the probiotic strain P. freudenreichii WT (wild-type) or a YEL culture of the mutant strain (ΔslpB). The means and standard deviations are calculated from 6 animals per group from 3 independent replicates and each quantification was done in triplicate (technical triplicates). Asterisks represent statistically significant differences between strains and were indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001, and ****p < 0.0001.