Figure 3. Propionibacterium freudenreichii WT strain prevents weight loss in 5-FU-treated mice .

(A) Time-course of body weight for mice receiving YEL culture medium YEL (YEL control), the probiotic strain P. freudenreichii 129 WT (wild-type), or the mutant strain P. freudenreichii (ΔslpB). Black lines correspond to the groups injected with saline i.p. and red lines to the groups injected with 5-FU i.p. (B) Weight loss observed after 5-FU injection and differences across groups. The means and standard deviations are calculated from daily weighing of 18 animals per group (Three independent replicates with 6 animals per group). Asterisks represent statistically significant differences as follows: ^* p <0.05; ^** p <0.01; and ^*** p <0.001.