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. 2019 Dec 31;10(68):7198–7219. doi: 10.18632/oncotarget.27319

Figure 5. Propionibacterium freudenreichii WT strain protects villus architecture and Paneth cells secretory granules density during 5-FU-induced mucositis .

Figure 5

Morphometric analysis of villus height (A), crypt depth (B) and ratio villus height/crypt depth (C) of mice treated with culture media YEL (control), probiotic strain P. freudenreichii WT and mutant strain P. freudenreichii ΔslpB or without treatment (water) following 5-FU or saline administration. Microscopic morphometric analysis of Paneth cell secretory granules (D) of mice treated with culture media YEL (control), probiotic strain P. freudenreichii WT and mutant strain P. freudenreichii ΔslpB or without treatment (water) following 5-FU or saline administration. Values were obtained using objective magnification at 40x by measuring ten random images of the ileum of mice. The means and standard deviations are calculated from ileum section of 18 animals per group (Three independent replicates with 6 animals per group). Asterisks represent statistically significant differences as follows: * p <0.05; ** p <0.01; *** p <0.001; **** p <0.0001.