Skip to main content
. 2020 Jan 3;40(2):e00364-19. doi: 10.1128/MCB.00364-19

FIG 8.

FIG 8

Effect of LXRs on cholesterol biosynthetic gene expression. C57BL/6 and Lxrα−/−/Lxrβ−/− BMDM were treated with the vehicle or 100 ng/ml KLA for the times shown. Following treatment, mRNA levels of Hmgcr (A), Cyp51a1 (B), Fdft (C), and Sqle (D) were quantified by real-time PCR and normalized to the value for cyclophilin. *, statistically significant difference from the vehicle control within the same genotype; **, statistically significant difference between C57BL/6 and Lxrα−/−/Lxrβ−/− vehicle controls determined by 2-way ANOVA (P ≤ 0.05; n = 8).